Digestive enzyme supplements have become increasingly popular for those seeking relief from digestive discomfort, bloating, and other gastrointestinal issues. With hundreds of options available on Amazon, finding the right product can be overwhelming. This comprehensive guide examines the top-rated digestive enzyme supplements on Amazon, analyzing their ingredients, effectiveness, user reviews, and overall value to help you make an informed decision.
“Say goodbye to discomfort after meals – try Digestive Enzyme Supplements and feel the change!”
What Are Digestive Enzymes and Why Take Them? 🧪
Digestive enzymes are specialized proteins that help break down food into nutrients your body can absorb. While your body naturally produces enzymes in the pancreas, salivary glands, and small intestine, some people may benefit from supplementation due to:
- Age-related decline in natural enzyme production
- Specific digestive conditions like IBS, SIBO, or pancreatic insufficiency
- Food intolerances (lactose, gluten sensitivity)
- General digestive discomfort after meals
- Nutrient malabsorption concerns
The most common digestive enzymes in supplements include:
- Amylase: Breaks down carbohydrates and starches
- Protease: Digests proteins
- Lipase: Breaks down fats
- Lactase: Digests lactose (milk sugar)
- Alpha-galactosidase: Helps digest complex sugars in beans and vegetables
- Cellulase: Breaks down plant cell walls and fibers
How We Evaluated These Products đź“Š
Our comprehensive assessment included:
- Ingredient quality and transparency: Types of enzymes, potency measurements, additional ingredients
- Value for money: Cost per serving relative to enzyme variety and potency
- User experience: Amazon star ratings, volume of reviews, and common feedback themes
- Brand reputation: Company history, manufacturing practices, third-party testing
- Formula design: Targeted vs. broad-spectrum approach, allergen considerations
Top 10 Digestive Enzyme Supplements on Amazon in 2025 🏆
1. Enzymedica Digest Gold (4.6/5 stars, 12,000+ reviews)
Price: $44.99 for 90 capsules (45-90 servings)
Key Ingredients: Thera-blend™ enzymes (amylase, protease, lipase, cellulase), ATP, magnesium citrate
Highlights:
- Highest potency multi-enzyme formula on the market
- Patented Thera-blend™ technology works throughout the entire digestive system
- Contains no fillers, binders, or artificial ingredients
- Vegan, non-GMO, and free from major allergens
What Users Love: Customers consistently report significant reduction in bloating, gas, and indigestion, even after heavy meals. Many users with chronic digestive issues mention this is the only product that’s provided consistent relief.
Potential Drawbacks: Premium price point, may be too potent for beginners.
One reviewer writes: “After trying at least 5 different enzyme brands, Digest Gold is the only one that consistently prevents the bloating and discomfort I used to experience after meals. Worth every penny!”
2. NOW Super Enzymes (4.5/5 stars, 18,000+ reviews)
Price: $17.99 for 180 capsules (90 servings)
Key Ingredients: Betaine HCl, ox bile extract, pancreatin, papain, bromelain, amylase, protease, lipase
Highlights:
- Excellent value for comprehensive enzyme blend
- Includes HCl and ox bile for additional digestive support
- Trusted brand with 50+ years in the supplement industry
- GMP certified facility
What Users Love: Budget-friendly option without sacrificing quality or effectiveness. Many reviewers appreciate the addition of betaine HCl for low stomach acid support.
Potential Drawbacks: Contains animal-derived ingredients (not suitable for vegetarians/vegans), some users report mild heartburn.
“These enzymes have changed my life,” shares one reviewer. “I’ve struggled with bloating for years, but within days of starting these, I noticed a dramatic difference in how I feel after eating.”
3. Pure Encapsulations Digestive Enzymes Ultra (4.7/5 stars, 7,500+ reviews)
Price: $38.90 for 90 capsules (30-45 servings)
Key Ingredients: 13 different digestive enzymes including amylase, protease, lipase, lactase, cellulase, phytase, and more
Highlights:
- Physician-trusted professional-grade formula
- Free from all major allergens and artificial ingredients
- Third-party tested for purity and potency
- Enhanced with carbohydrase blend for complete carbohydrate digestion
What Users Love: Customers with sensitive systems and multiple food intolerances report excellent results with minimal side effects. Many appreciate the clean, allergen-free formulation.
Potential Drawbacks: Higher cost per serving, smaller bottle size.
One verified purchase review states: “My naturopath recommended this specific brand. It’s more expensive than others I’ve tried, but the quality is noticeable and my digestion has improved tremendously.”
4. Garden of Life Dr. Formulated Enzymes Organic Digest+ (4.5/5 stars, 9,800+ reviews)
Price: $33.59 for 90 capsules (30-45 servings)
Key Ingredients: 29 powdered fruits and vegetables, 13 digestive enzymes, probiotic blend (1.5 billion CFU)
Highlights:
- USDA organic certification
- Combines enzymes with probiotics for comprehensive digestive support
- Raw, plant-based formula with no fillers
- Includes specialized enzymes for gluten and dairy digestion
What Users Love: Plant-based consumers appreciate the organic ingredients and whole-food approach. Many users report improved digestion of problematic foods like dairy and gluten.
Potential Drawbacks: Some users note the capsules have a strong herbal smell.
“As someone with both gluten and dairy sensitivities, this has been a game-changer,” writes one reviewer. “It doesn’t completely eliminate my need to avoid these foods, but it’s amazing for those times when I’m eating out and can’t control all ingredients.”
5. Doctor’s Best Digestive Enzymes (4.6/5 stars, 11,300+ reviews)
Price: $19.99 for 90 capsules (45 servings)
Key Ingredients: Full-spectrum plant-based enzymes including amylase, protease 1-4, peptidase, alpha-galactosidase, lactase, lipase, cellulase
Highlights:
- Excellent value for a comprehensive formula
- Non-GMO, gluten-free, soy-free, and vegetarian
- Fungal-derived enzymes active in various pH environments
- Transparent labeling of enzyme activity units
What Users Love: Budget-conscious shoppers appreciate the combination of quality and affordability. Many reviewers mention this product helps with both everyday digestion and occasional digestive distress.
Potential Drawbacks: Some users report needing to take more than the recommended dosage for maximum effectiveness.
“I’ve been using these for over two years and they’ve made a tremendous difference in my daily comfort,” says one long-term user. “No more bloating or that heavy feeling after meals.”
6. Zenwise Digestive Enzymes with Prebiotics & Probiotics (4.5/5 stars, 24,000+ reviews)
Price: $24.97 for 180 capsules (60 servings)
Key Ingredients: Multi-enzyme complex, inulin prebiotic, probiotic blend (1 billion CFU), turmeric, ginger, green papaya, apple pectin
Highlights:
- Complete digestive solution with enzymes, prebiotics, and probiotics
- Added botanicals to soothe digestive discomfort
- Specifically formulated to help with gas, bloating, and constipation
- Made in a GMP certified facility in the USA
What Users Love: The 3-in-1 approach combines multiple digestive supports in one product. Many users with IBS and chronic digestive issues report significant improvement.
Potential Drawbacks: Larger capsule size, probiotic count is lower than dedicated probiotic supplements.
One enthusiastic reviewer writes: “After years of struggling with bloating and irregularity, these have been life-changing. I can eat foods I previously had to avoid without discomfort.”
7. MaryRuth’s Digestive Food Enzymes (4.6/5 stars, 5,800+ reviews)
Price: $29.95 for 60 capsules (30 servings)
Key Ingredients: Comprehensive blend of 18 plant-based enzymes with specific formulation for protein, fat, carbohydrate, fiber, and dairy digestion
Highlights:
- Vegan, non-GMO, soy-free, dairy-free, and gluten-free
- Delayed-release capsules protect enzymes from stomach acid
- No synthetic fillers or artificial ingredients
- Woman-owned, family business with strong customer service
What Users Love: Customers with multiple food sensitivities and dietary restrictions appreciate the clean formula. Many mention excellent customer service experiences.
Potential Drawbacks: Higher price point per serving, smaller bottle size.
“I have multiple autoimmune conditions and am very particular about supplements,” shares one reviewer. “These enzymes are among the cleanest I’ve found and have noticeably improved my digestion without any reactions.”
8. Source Naturals Daily Digestive Enzymes (4.5/5 stars, 4,900+ reviews)
Price: $24.50 for 240 capsules (120 servings)
Key Ingredients: Comprehensive blend including amylase, protease, lipase, cellulase, lactase, alpha-galactosidase, plus bromelain and papain
Highlights:
- Excellent value with high number of servings per bottle
- Vegetarian-friendly enzyme blend
- Active in a broad pH range throughout the digestive tract
- Established brand with 40+ years in the supplement industry
What Users Love: Budget-friendly option with a high quantity of capsules per bottle, making it ideal for daily, long-term use. Many reviewers mention improved digestion of challenging foods.
Potential Drawbacks: Contains some fillers, capsules may stick together in humid environments.
“I’ve tried many digestive enzymes over the years, but keep coming back to these,” notes one reviewer. “They’re affordable enough for daily use and effective enough that I notice when I forget to take them.”
9. Healthy Origins DigestMORE (4.4/5 stars, 3,200+ reviews)
Price: $27.99 for 90 capsules (30-45 servings)
Key Ingredients: Full-spectrum plant-based enzymes plus herbal digestive supporters including ginger, marshmallow root, peppermint, and fennel
Highlights:
- Combines enzymes with traditional digestive herbs
- Vegetarian, non-GMO, and free from common allergens
- Designed for more severe digestive issues
- Higher potency of key enzymes than many competitors
What Users Love: Those with chronic digestive issues appreciate the addition of soothing herbs alongside potent enzymes. Many users report it works when other products have failed.
Potential Drawbacks: Some users report mild herbal aftertaste, may cause temporary changes in bowel movements while adjusting.
“After being diagnosed with IBS and trying countless products, this is the only one that has consistently provided relief,” writes one customer. “The combination of enzymes and herbs seems to be the key.”
10. American Health Super Papaya Enzyme Plus (4.5/5 stars, 7,300+ reviews)
Price: $15.99 for 360 chewable tablets (120 servings)
Key Ingredients: Papaya fruit, papain, amylase, protease, lipase, bromelain
Highlights:
- Convenient chewable tablets with pleasant taste
- Ideal for occasional digestive support after large meals
- Can be taken as needed rather than daily
- Long-standing product with decades of positive consumer experience
What Users Love: The pleasant-tasting chewable format makes these enzymes easy to take anywhere without water. Many users keep these on hand for restaurant meals or holiday feasts.
Potential Drawbacks: Contains some sugar and natural flavors, not as comprehensive as capsule formulations.
“I’ve been using these for over 15 years,” shares a long-time customer. “They’re perfect to keep in my purse for dining out, and the minty-sweet taste is actually enjoyable.”
How to Choose the Right Digestive Enzyme Supplement for You 🔎
Consider these factors when selecting from the top products:
1. Your Specific Digestive Concerns
- General digestive support: Broad-spectrum formulas like Enzymedica Digest Gold or NOW Super Enzymes
- Food-specific intolerances: Products with targeted enzymes (lactase for dairy, DPP-IV for gluten)
- IBS or chronic issues: Formulas with added soothing herbs like Healthy Origins DigestMORE
- Low stomach acid: Products containing HCl like NOW Super Enzymes
2. Dietary Preferences and Restrictions
- Vegan/vegetarian: Plant-based options like Garden of Life, MaryRuth’s, or Doctor’s Best
- Allergen concerns: Hypoallergenic formulations like Pure Encapsulations
- Clean label priority: Minimalist formulas without fillers or additives
3. Format and Usage
- Daily preventive use: Capsule formulations with 30-90 day supply
- Occasional/as-needed: Chewables like American Health Super Papaya
- Comprehensive gut support: Products with added probiotics and prebiotics like Zenwise
4. Budget Considerations
- Premium, therapeutic-grade: Enzymedica Digest Gold, Pure Encapsulations
- Mid-range, quality options: Zenwise, Garden of Life
- Budget-friendly: NOW Super Enzymes, Source Naturals
FAQs About Digestive Enzyme Supplements âť“
Are digestive enzymes safe?
Most digestive enzyme supplements are generally safe for healthy adults when taken as directed. However, some people may experience mild digestive upset when first starting. Those with specific health conditions, pregnant or nursing women, and people taking medications should consult healthcare providers before use.
When should I take digestive enzymes?
For optimal effectiveness, most digestive enzymes should be taken just before or at the beginning of meals. Some formulations specify “with meals” on their labels.
How quickly do digestive enzymes work?
Most digestive enzymes begin working within the meal they’re taken with. Users typically notice effects within a few days of consistent use, though some report immediate improvement in post-meal comfort.
Can I take digestive enzymes long-term?
Many people take digestive enzymes daily for extended periods without issues. However, it’s advisable to periodically assess whether they’re still needed and consult healthcare providers about long-term use.
Are there any medication interactions with digestive enzymes?
Digestive enzymes may interact with certain medications, including blood thinners, antibiotics, and antacids. Always consult with a healthcare provider if you’re taking medications.
Conclusion: Finding Your Ideal Digestive Support 🌿
The best digestive enzyme supplement for you depends on your specific needs, preferences, and budget. All ten products featured in this guide have strong track records of customer satisfaction and quality formulation, with Enzymedica Digest Gold, NOW Super Enzymes, and Pure Encapsulations Digestive Enzymes Ultra consistently earning top spots for effectiveness across different user needs.
If you’re new to digestive enzymes, consider starting with a moderate-potency broad-spectrum formula and adjusting based on your results. For those with specific digestive concerns, targeted formulations may provide more relief. And remember that digestive enzymes work best as part of a comprehensive approach to digestive health that includes proper diet, hydration, and stress management.
With the right enzyme supplement, many Amazon customers report significant improvements in digestive comfort, nutrient absorption, and overall quality of life—making these products a valuable tool in your digestive wellness toolkit.
Note: Prices and ratings are accurate as of publication date and are subject to change. Always consult with a healthcare professional before starting any new supplement regimen.
